Hsieh Lab | UTSA

Neurodevelopment And Adult
Neurogenesis in Epilepsy

Our Mission

The Hsieh lab wants to understand the mechanisms underlying neural development and adult neurogenesis. Working primarily in mouse models and in vitro systems such as patient-derived induced pluripotent stem cells, the Hsieh lab studies the function of genes involved in epilepsy disorders. We study mesial temporal lobe epilepsy, the most common intractable epilepsy in adults, and genetic epilepsies, a group of rare neurodevelopmental disorders characterized by early onset seizures. We also collaborate with labs to study the role of genes that contribute to hyperexcitability in early- and late-onset degenerative diseases like Alzheimer’s disease. The goal of the Hsieh lab is to find ways to target abnormal functions of genes in developmental and degenerative conditions.

Overview of our Research

The Hsieh laboratory focuses on 4 major areas:

(1) iPSC Models & Genetic Epilepsies
(2) Adult Hippocampal Neurogenesis & Epilepsy
(3) Human 3D Brain Organoid Models
(4) UTSA Stem Cell Core and Patient Recruitment



New NIH grant awards! R21 to Parul Varma and Vanesa Nieto-Estevez to study CHD2-associated epilepsy and a Hsieh lab R01 to study the mechanisms of aberrant adult born granule neurons in epilepsy


San Antonio Express News article featuring Hsieh lab research and the UTSA Brain Health Consortium


Erin Hurley's New Publication on PSEN1 organoids in Stem Cell Reports


Jenny Hsieh, Ph.D.

Jenny Hsieh, Ph.D.

Principal Investigator

  • Professor and Department Chair, Neuroscience, Developmental and Regenerative Biology
  • Semmes Foundation Distinguished Chair in Cell Biology
  • Director, UTSA Brain Health Consortium