Hsieh Lab | UTSA

Neurodevelopment And Adult
Neurogenesis in Epilepsy

Our Mission

The Hsieh lab wants to understand the mechanisms underlying neural development and adult neurogenesis. Working primarily in mouse models and in vitro systems such as patient-derived induced pluripotent stem cells, the Hsieh lab studies the function of genes involved in epilepsy disorders. We study mesial temporal lobe epilepsy, the most common intractable epilepsy in adults, and genetic epilepsies, a group of rare neurodevelopmental disorders characterized by early onset seizures. We also collaborate with labs to study the role of genes that contribute to hyperexcitability in early- and late-onset degenerative diseases like Alzheimer’s disease. The goal of the Hsieh lab is to find ways to target abnormal functions of genes in developmental and degenerative conditions.

Overview of our Research

The Hsieh laboratory focuses on 4 major areas:

(1) iPSC Models & Genetic Epilepsies
(2) Adult Hippocampal Neurogenesis & Epilepsy
(3) Human 3D Brain Organoid Models
(4) UTSA Stem Cell Core and Patient Recruitment



Aranis Muniz Perez is accepted into graduate school at Emory University


Zacharie Maloney is awarded a grant from the American Heart Association


New preprint on bioRxiv on the Dual Effects of ARX poly-alanine mutations in human cortical and interneuron development


Jenny Hsieh, Ph.D.

Jenny Hsieh, Ph.D.

Principal Investigator

  • Professor and Department Chair, Neuroscience, Developmental and Regenerative Biology
  • Semmes Foundation Distinguished Chair in Cell Biology
  • Director, UTSA Brain Health Consortium