Selected Publications

APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoids. (2024)

bioRxiv Meyer-Acosta KK, Diaz-Guerra E, Varma P, Aruk A, Mirsadeghi S, Perez AM, Rafati Y, Hosseini A, Nieto-Estevez V, Giugliano M, Navara C, Hsieh J

doi: 10.1101/2024.10.07.617044

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Dual effects of ARX poly-alanine mutations in human cortical and interneuron development. (2024)

BioRxiv Nieto-Estevez V, Varma P, Mirsadeghi S, Caballero J, Gamero-Alameda S, Hosseini A, Goswami S, Silvosa MJ, Thodeson DM, Lybrand ZR, Giugliano M, Navara C, Hsieh J

doi: 10.1101/2024.01.25.577271

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Integrating adult neurogenesis and human brain organoid models to advance epilepsy and associated behavioral research. (2024)

Epilepsy Behav Adeyeye A, Mirsadeghi S, Gutierrez M, Hsieh J

doi: 10.1016/j.yebeh.2024.109982

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Prenatal SARS-CoV-2 infection results in neurodevelopmental and behavioral outcomes in mice. (2024)

JCI Insights McMahon CL, Hurley EM, Perez AM, Lodge D, and Hsieh J

JCI Insight. 2024 May 23:e179068. doi: 10.1172/jci.insight.179068

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Seizure-induced LIN28A disrupts pattern separation via aberrant hippocampal neurogenesis. (2024)

JCI Insights Choi IY, Cha JH, Kim SY, Hsieh J, and Cho KO

https://insight.jci.org/articles/view/175627

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Familial Alzheimer’s disease-associated PSEN1 mutations affect neurodevelopment through increased Notch signaling (2023)

Stem Cell Reports. Erin Hurley, Pawel Mozolewski, Radek Dobrowolski, Jenny Hsieh

https://doi.org/10.1016/j.stemcr.2023.05.018

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Fetal brain vulnerability to SARS-CoV-2 infection (2023)

Brain, Behavior, and Immunity. McMahon CL, Castro J, Silvas J, Muniz Perez A, Estrada M, Carrion R Jr, Hsieh J

https://doi.org/10.1016/j.bbi.2023.06.015

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Buprenorphine Exposure Alters the Development and Migration of Interneurons in the Cortex (2022)

Front. Mol. Neurosci. Nieto-Estévez V, Donegan JJ, McMahon CL, Elam HB, Chavera TA, Varma P, Berg KA, Lodge DJ, Hsieh J

10.3389/fnmol.2022.889922/full

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Gestational buprenorphine exposure disrupts dopamine neuron activity and related behaviors in adulthood (2022)

eNeuro. Elam HB, Donegan JJ, Hsieh J, Lodge DJ

doi: 10.1523/ENEURO.0499-21.2022

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HDAC1 Regulates Neuronal Differentiation (2022)

Front. Mol. Neurosci. Nieto-Estevez V, Changarathil G, Adeyeye AO, Coppin MO, Kassim RS, Zhu J, Hsieh J.

10.3389/fnmol.2021.815808

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A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy. (2021)

Nat Commun. Lybrand ZR, Goswami S, Zhu J, Jarzabek V, Merlock N, Aktar M, Smith C, Zhang L, Varma P, Cho KO, Ge S, Hsieh J.

10.1038/s41467-021-21649-8.

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Novel Targets of SARS-CoV-2 Spike Protein in Human Fetal Brain Development Suggest Early Pregnancy Vulnerability. (2021)

Front Neurosci. Varma P, Lybrand ZR, Antopia MC, Hsieh J.

10.3389/fnins.2020.614680.

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SARS-CoV-2 targets glial cells in human cortical organoids. (2021)

Stem Cell Reports. McMahon CL, Staples H, Gazi M, Carrion R, Hsieh J.

10.1016/j.stemcr.2021.01.016

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Circuit Integration Initiation of New Hippocampal Neurons in the Adult Brain. (2020)

Cell Rep. Yang CH, Di Antonio A, Kirschen GW, Varma P, Hsieh J, Ge S.

10.1016/j.celrep.2019.12.084.

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Human Brain Organoid Models of Developmental Epilepsies (2020)

Epilepsy Curr. Nieto-Estévez V, Hsieh J.

10.1177/1535759720949254.

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Role of RB1 in human embryonic stem cell-derived retinal organoids. (2020)

Developmental Biology. Zheng C, Schneider J, and Hsieh J.

10.1016/j.ydbio.2020.03.011.

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One-Hit Wonders and 2-Hit Tubers: A Second-Hit to TSC2 Causes Tuber-Like Cells in Spheroids. (2019)

Epilepsy Curr. Goswami S, Hsieh J.

10.1177/1535759718822036.

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Stem cells: a path towards improved epilepsy therapies. (2019)

Neuropharmacology. Lybrand Z, Goswami S, Hsieh J.

10.1016/j.neuropharm.2019.107781.

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Targeting seizure-induced neurogenesis in a clinically-relevant time period leads to transient but not persistent seizure reduction. (2019)

J Neurosci. Varma P., Brulet R., Zhang L., and Hsieh J.

10.1523/ JNEUROSCI.0920-19.2019.

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CHD2: One Gene, Many Roles. (2018)

Neuron. Nieto-Estevez V, Hsieh J.

10.1016/j.neuron.2018.11.036.

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Genome-Wide Identification of Transcription Factor-Binding Sites in Quiescent Adult Neural Stem Cells. (2018)

Methods Mol Biol. Mukherjee S, Hsieh J.

10.1007/978-1-4939-7371-2_19.

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Neural stem cells and epilepsy: functional roles and disease-in-a-dish models. (2018)

Cell Tissue Res. Thodeson DM, Brulet R, Hsieh J.

10.1007/s00441-017-2675-z.

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Mice with conditional NeuroD1 knockout display reduced aberrant hippocampal neurogenesis but no change in epileptic seizures. (2017)

Exp Neurol. Brulet R, Zhu J, Aktar M, Hsieh J, Cho KO.

10.1016/j.expneurol.2017.04.005.

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NEUROD1 Instructs Neuronal Conversion in Non-Reactive Astrocytes. (2017)

Stem Cell Reports. Brulet R, Matsuda T, Zhang L, Miranda C, Giacca M, Kaspar BK, Nakashima K, Hsieh J.

10.1016/j.stemcr.2017.04.013.

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Retinoblastoma protein controls growth, survival and neuronal migration in human cerebral organoids (2017)

Development. Matsui T, Nieto-Estévez V, Kyrychenko S, Schneider JW, Hsieh J.

10.1242/dev.143636.

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You Have Brains in Your Head, You Have Organoids in Your Dish, You Can Steer Yourself in any Direction You Wish. (2017)

Epilepsy Curr. Thodeson DM, Hsieh J.

10.5698/1535-7597.17.5.311.

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Genetics and Epigenetics in Adult Neurogenesis. (2016)

Cold Spring Harb Perspect Biol. Hsieh J, Zhao X.

10.1101/cshperspect.a018911.

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Neurogenesis in Cancun: where science meets the sea. (2016)

Development. Hsieh J, Zhang CL.

10.1242/dev.138412.

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REST regulation of gene networks in adult neural stem cells. (2016)

Nat Comm. Mukherjee S, Brulet R, Zhang L, Hsieh J.

10.1038/ncomms13360.

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The REST remodeling complex protects genomic integrity during embryonic neurogenesis. (2016)

Elife. Nechiporuk T, McGann J, Mullendorff K, Hsieh J, Wurst W, Floss T, Mandel G.

10.7554/eLife.09584.

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Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline. (2015)

Nat Comm. Cho K, Ito N, Lybrand ZR, Brulet R, Tafacory F, Zhang L, Good L, Ure K, Kernie SG, Birnbaum SG, Scharfman HE, Eisch AJ, Hsieh J.

10.1038/ncomms7606.

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Inducible knockout of Mef2a, -c, and -d from nestin-expressing stem/progenitor cells and their progeny unexpectedly uncouples neurogenesis and dendritogenesis in vivo. (2015)

FASEB J. Latchney SE, Jiang Y, Petrik DP, Eisch AJ, Hsieh J.

10.1096/fj.15-275651.

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Suppression of adult neurogenesis increases the acute effects of kainic Acid. (2015)

Exp Neurol. Iyengar SS, LaFrancois JJ, Friedman D, Drew LJ, Denny CA, Burghardt NS, Wu MV, Hsieh J, Hen R, Scharfman HE.

10.1016/j.expneurol.2014.11.009.

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HDAC3 controls gap 2/mitosis progression in adult neural stem/progenitor cells by regulating CDK1 levels. (2014)

Exp Neurol. Jiang Y, Hsieh J.

10.1016/j.expneurol.2014.11.009.

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Neural stem cells, excited (2013)

Science Hsieh J, Schneider JW. Neuroscience

10.1126/science.1237576.

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On your (methyl) mark, get TET1, go! (2013)

Cell Stem Cell Mukherjee S, Hsieh J

10.1016/j.stem.2013.07.011.

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Epigenetics and epilepsy (2012)

Epilepsia Roopra A, Dingledine R, Hsieh J

10.1111/epi.12030.

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Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule (2012)

FASEB J Petrik D, Jiang Y, Birnbaum SG, Powell CM, Kim MS, Hsieh J, Eisch AJ.

10.1096/fj.11-201426.

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Orchestrating transcriptional control of adult neurogenesis (2012)

Genes Dev Hsieh J

10.1101/gad.187336.112.

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Profiling of REST-Dependent microRNAs Reveals Dynamic Modes of Expression (2012)

Front Neurosci Gao Z, Ding P, Hsieh J

10.3389/fnins.2012.00067

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Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression (2011)

Differentiation Ling Zhang, Peng Li, Tiffany Hsu, Jay Schneider, Robert Bachoo, and Jenny Hsieh

10.1016/j.diff.2011.02.005.

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The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells. (2011)

Neuroscience Zhengliang Gao, Kerstin Ure, Mostafa Nashaat, Laura Yuan, Robert Hammer, and Jenny Hsieh

10.1523/JNEUROSCI.

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Discovery of a proneurogenic, neuroprotective chemical (2010)

neuroprotective chemical AA Pieper, S Xie, E Capota, SJ Estill, J Zhong, JM Long, GL Becker, P Huntington, SE Goldman, CH Shen, M Capota, JK Britt, T Kotti, K Ure, DJ Brat, NS Williams, KS MacMillan, J Naidoo, L Melito, J Hsieh, J De Brabander, JM Ready, and SL McKnight

10.1016/j.cell.2010.06.018.

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Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: unraveling the genome to understand the mind (2010)

Neurobiology of Disease Jenny Hsieh, and Amelia J Eisch

10.1016/j.nbd.2010.01.008

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MicroRNA regulation of neural stem cells and neurogenesis (2010)

Neuroscience Yanhong Shi, Xinyu Zhao, Jenny Hsieh, Hynek Wichterle, Soren Impey, Sourav Banerjee, Pierre Neveu, and Kenneth S. Kosik

10.1523/JNEUROSCI.4280-10.2010.

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Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells. (2010)

Neuroscience JL Ables, NA Decarolis, MA Johnson, PD Rivera, Z Gao, DC Cooper, F Radtke, J Hsieh, and AJ Eisch

10.1523/JNEUROSCI.4721-09.2010.

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HDAC1 and HDAC2 Regulate Oligodendrocyte Differentiation By Disrupting β-Catenin-TCF Interaction (2009)

Nature Neuroscience Feng Ye, Ying Chen, Thao Nguyen Hoang, Rusty Montgomery, Hong Bu, Xiang-hui Zhao, Tom Hu, Johan van Es, Hans Clevers, Makoto Taketo, Jenny Hsieh, Rhonda Bassel-Duby, Eric N. Olson, and Q. Richard Lu

10.1038/nn.2333.

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Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development (2009)

Proc Natl Acad Sci USA Rusty Montgomery, Jenny Hsieh, Ana Barbosa, James Richardson, and Eric N. Olson

10.1073/pnas.0902750106.

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Neurod1 is essential for the survival and maturation of adult-born neurons (2009)

Nature Neuroscience Zhengliang Gao, Kerstin Ure, Jessica Ables, Diane Lagace, Sandra Goebbels, Klause-Armin Nave, Amelia Eisch, and Jenny Hsieh

10.1038/nn.2385

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The oligodendrocyte-specific G-protein coupled receptor GPR17 is a cell-intrinsic timer of myelination (2009)

Nature Neuroscience Ying Chen, Heng Wu, Hisami Koito, Jianrong Li, Jenny Hoang, Shuzong Wang, Sabine S. Escobar, Alex Gow, Heather A. Arnett, Bruce D. Trapp, Nitin J. Karandikar, Jenny Hsieh and Q. Richard Lu

10.1038/nn.2410

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Wnt-mediated activation of NeuroD1 and retroelements during adult neurogenesis (2009)

Nature Neuroscience Tomoko Kuwabara, Jenny Hsieh, Alysson Muotri, Gene Yeo, Masaki Warashina, D. Chichung Lie, Lynne Moore, Kinichi Nakashima, Makoto Asashima, Fred H. Gage

10.1038/nn.2360.

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Cardiogenic small molecules that enhance stem cell function in myocardial repair (2008)

Proc Natl Acad Sci USA Hesham Sadek, Britta Hannack, Elizabeth Choe, Jessica Wang, Shuaib Latif, Mary G. Garry, Daniel J. Garry, Jamie Longgood, Douglas E. Frantz, Eric N. Olson, Jenny Hsieh, and Jay W. Schneider

10.1073/pnas.0711507105.

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Epigenetic regulation of neural cell differentiation plasticity in the adult mammalian brain (2008)

Proc Natl Acad Sci USA Jun Kohyama, Takuro Kojima, Eriko Takatsuka, Toru Yamashita, Jun Namiki, Jenny Hsieh, Fred H. Gage, Masakazu Namihira, Hideyuki Okano, Kazunobu Sawamoto, and Kinichi Nakashima

10.1073/pnas.0808417105.

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Small-molecule activation of neuronal cell fate (2008)

Nature Chemical Biology Jay W. Schneider, Zhengliang Gao, Shijie Li, Midhat Farooqi, Tie-Shan Tang, Ilya Bezprozvanny, Douglas E. Frantz, and Jenny Hsieh

10.1038/nchembio.95

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Epigenetic modulation of seizure-induced neurogenesis and cognitive decline (2007)

Neuroscience Sebastian Jessberger, Kinichi Nakashima, Gregory Clemenson, Eunice Mejia, Emily Mathews, Kerstin Ure, Shiori Ogawa, Christopher M. Sinton, Fred H. Gage, and Jenny Hsieh

10.1523/JNEUROSCI.0110-07.2007

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Chromatin remodeling in neural development and plasticity (2005)

Current Opinion in Cell Biology Jenny Hsieh, and Fred H. Gage

10.1016/j.ceb.2005.09.002

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A small modulatory dsRNA specifies the fate of adult neural stem cells (2004)

Cell Tomoko Kuwabara, Jenny Hsieh, Kinichi Nakashima, Kazunari Taira, and Fred H. Gage

10.1016/s0092-8674(04)00248-x

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Epigenetic control of neural stem cell fate (2004)

Current Opinion in Genetics & Development Jenny Hsieh, and Fred H. Gage

10.1016/j.gde.2004.07.006

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HDAC inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells (2004)

Proc Natl Acad Sci USA Jenny Hsieh, Kinichi Nakashima, Tomoko Kuwabara, Eunice Mejia, and Fred H. Gage.

10.1073/pnas.0407643101

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IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes (2004)

Cell Biology Jenny Hsieh, James B. Aimone, Brian K. Kaspar, Tomoko Kuwabara, Kinichi Nakashima, and Fred H. Gage

10.1083/jcb.200308101

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Increased neurogenesis in dentate gyrus of long-lived Ames dwarf mice (2004)

Endocrinology Liou Y. Sun, M. Steven Evans, Jenny Hsieh, Jacob Panici, and Andrzej Bartke

10.1210/en.2004-1115.

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Recognition and silencing of repeated DNA. (2000)

Annual Review of Genetics Jenny Hsieh, and Andrew Fire

10.1146/annurev.genet.34.1.187

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The RING finger/B-Box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans (1999)

Genes and Development Jenny Hsieh, Jing Liu, Steve Kostas, Chieh Chang, Paul Sternberg, and Andrew Fire

10.1101/gad.13.22.2958

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