Selected Publications
Dual effects of ARX poly-alanine mutations in human cortical and interneuron development. (2024)
BioRxiv Nieto-Estevez V, Varma P, Mirsadeghi S, Caballero J, Gamero-Alameda S, Hosseini A, Goswami S, Silvosa MJ, Thodeson DM, Lybrand ZR, Giugliano M, Navara C, Hsieh J
doi: 10.1101/2024.01.25.577271
View PublicationPrenatal SARS-CoV-2 infection results in neurodevelopmental and behavioral outcomes in mice. (2024)
JCI Insights McMahon CL, Hurley EM, Perez AM, Lodge D, and Hsieh J
JCI Insight. 2024 May 23:e179068. doi: 10.1172/jci.insight.179068
View PublicationSeizure-induced LIN28A disrupts pattern separation via aberrant hippocampal neurogenesis. (2024)
JCI Insights Choi IY, Cha JH, Kim SY, Hsieh J, and Cho KO
https://insight.jci.org/articles/view/175627
View PublicationFamilial Alzheimer’s disease-associated PSEN1 mutations affect neurodevelopment through increased Notch signaling (2023)
Stem Cell Reports. Erin Hurley, Pawel Mozolewski, Radek Dobrowolski, Jenny Hsieh
https://doi.org/10.1016/j.stemcr.2023.05.018
View PublicationFetal brain vulnerability to SARS-CoV-2 infection (2023)
Brain, Behavior, and Immunity. McMahon CL, Castro J, Silvas J, Muniz Perez A, Estrada M, Carrion R Jr, Hsieh J
https://doi.org/10.1016/j.bbi.2023.06.015
View PublicationBuprenorphine Exposure Alters the Development and Migration of Interneurons in the Cortex (2022)
Front. Mol. Neurosci. Nieto-Estévez V, Donegan JJ, McMahon CL, Elam HB, Chavera TA, Varma P, Berg KA, Lodge DJ, Hsieh J
10.3389/fnmol.2022.889922/full
View PublicationGestational buprenorphine exposure disrupts dopamine neuron activity and related behaviors in adulthood (2022)
eNeuro. Elam HB, Donegan JJ, Hsieh J, Lodge DJ
doi: 10.1523/ENEURO.0499-21.2022
View PublicationHDAC1 Regulates Neuronal Differentiation (2022)
Front. Mol. Neurosci. Nieto-Estevez V, Changarathil G, Adeyeye AO, Coppin MO, Kassim RS, Zhu J, Hsieh J.
10.3389/fnmol.2021.815808
View PublicationA critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy. (2021)
Nat Commun. Lybrand ZR, Goswami S, Zhu J, Jarzabek V, Merlock N, Aktar M, Smith C, Zhang L, Varma P, Cho KO, Ge S, Hsieh J.
10.1038/s41467-021-21649-8.
View PublicationNovel Targets of SARS-CoV-2 Spike Protein in Human Fetal Brain Development Suggest Early Pregnancy Vulnerability. (2021)
Front Neurosci. Varma P, Lybrand ZR, Antopia MC, Hsieh J.
10.3389/fnins.2020.614680.
View PublicationSARS-CoV-2 targets glial cells in human cortical organoids. (2021)
Stem Cell Reports. McMahon CL, Staples H, Gazi M, Carrion R, Hsieh J.
10.1016/j.stemcr.2021.01.016
View PublicationCircuit Integration Initiation of New Hippocampal Neurons in the Adult Brain. (2020)
Cell Rep. Yang CH, Di Antonio A, Kirschen GW, Varma P, Hsieh J, Ge S.
10.1016/j.celrep.2019.12.084.
View PublicationHuman Brain Organoid Models of Developmental Epilepsies (2020)
Epilepsy Curr. Nieto-Estévez V, Hsieh J.
10.1177/1535759720949254.
View PublicationRole of RB1 in human embryonic stem cell-derived retinal organoids. (2020)
Developmental Biology. Zheng C, Schneider J, and Hsieh J.
10.1016/j.ydbio.2020.03.011.
View PublicationOne-Hit Wonders and 2-Hit Tubers: A Second-Hit to TSC2 Causes Tuber-Like Cells in Spheroids. (2019)
Epilepsy Curr. Goswami S, Hsieh J.
10.1177/1535759718822036.
View PublicationStem cells: a path towards improved epilepsy therapies. (2019)
Neuropharmacology. Lybrand Z, Goswami S, Hsieh J.
10.1016/j.neuropharm.2019.107781.
View PublicationTargeting seizure-induced neurogenesis in a clinically-relevant time period leads to transient but not persistent seizure reduction. (2019)
J Neurosci. Varma P., Brulet R., Zhang L., and Hsieh J.
10.1523/ JNEUROSCI.0920-19.2019.
View PublicationCHD2: One Gene, Many Roles. (2018)
Neuron. Nieto-Estevez V, Hsieh J.
10.1016/j.neuron.2018.11.036.
View PublicationGenome-Wide Identification of Transcription Factor-Binding Sites in Quiescent Adult Neural Stem Cells. (2018)
Methods Mol Biol. Mukherjee S, Hsieh J.
10.1007/978-1-4939-7371-2_19.
View PublicationNeural stem cells and epilepsy: functional roles and disease-in-a-dish models. (2018)
Cell Tissue Res. Thodeson DM, Brulet R, Hsieh J.
10.1007/s00441-017-2675-z.
View PublicationMice with conditional NeuroD1 knockout display reduced aberrant hippocampal neurogenesis but no change in epileptic seizures. (2017)
Exp Neurol. Brulet R, Zhu J, Aktar M, Hsieh J, Cho KO.
10.1016/j.expneurol.2017.04.005.
View PublicationNEUROD1 Instructs Neuronal Conversion in Non-Reactive Astrocytes. (2017)
Stem Cell Reports. Brulet R, Matsuda T, Zhang L, Miranda C, Giacca M, Kaspar BK, Nakashima K, Hsieh J.
10.1016/j.stemcr.2017.04.013.
View PublicationRetinoblastoma protein controls growth, survival and neuronal migration in human cerebral organoids (2017)
Development. Matsui T, Nieto-Estévez V, Kyrychenko S, Schneider JW, Hsieh J.
10.1242/dev.143636.
View PublicationYou Have Brains in Your Head, You Have Organoids in Your Dish, You Can Steer Yourself in any Direction You Wish. (2017)
Epilepsy Curr. Thodeson DM, Hsieh J.
10.5698/1535-7597.17.5.311.
View PublicationGenetics and Epigenetics in Adult Neurogenesis. (2016)
Cold Spring Harb Perspect Biol. Hsieh J, Zhao X.
10.1101/cshperspect.a018911.
View PublicationNeurogenesis in Cancun: where science meets the sea. (2016)
Development. Hsieh J, Zhang CL.
10.1242/dev.138412.
View PublicationREST regulation of gene networks in adult neural stem cells. (2016)
Nat Comm. Mukherjee S, Brulet R, Zhang L, Hsieh J.
10.1038/ncomms13360.
View PublicationThe REST remodeling complex protects genomic integrity during embryonic neurogenesis. (2016)
Elife. Nechiporuk T, McGann J, Mullendorff K, Hsieh J, Wurst W, Floss T, Mandel G.
10.7554/eLife.09584.
View PublicationAberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline. (2015)
Nat Comm. Cho K, Ito N, Lybrand ZR, Brulet R, Tafacory F, Zhang L, Good L, Ure K, Kernie SG, Birnbaum SG, Scharfman HE, Eisch AJ, Hsieh J.
10.1038/ncomms7606.
View PublicationInducible knockout of Mef2a, -c, and -d from nestin-expressing stem/progenitor cells and their progeny unexpectedly uncouples neurogenesis and dendritogenesis in vivo. (2015)
FASEB J. Latchney SE, Jiang Y, Petrik DP, Eisch AJ, Hsieh J.
10.1096/fj.15-275651.
View PublicationSuppression of adult neurogenesis increases the acute effects of kainic Acid. (2015)
Exp Neurol. Iyengar SS, LaFrancois JJ, Friedman D, Drew LJ, Denny CA, Burghardt NS, Wu MV, Hsieh J, Hen R, Scharfman HE.
10.1016/j.expneurol.2014.11.009.
View PublicationHDAC3 controls gap 2/mitosis progression in adult neural stem/progenitor cells by regulating CDK1 levels. (2014)
Exp Neurol. Jiang Y, Hsieh J.
10.1016/j.expneurol.2014.11.009.
View PublicationNeural stem cells, excited (2013)
Science Hsieh J, Schneider JW. Neuroscience
10.1126/science.1237576.
View PublicationOn your (methyl) mark, get TET1, go! (2013)
Cell Stem Cell Mukherjee S, Hsieh J
10.1016/j.stem.2013.07.011.
View PublicationEpigenetics and epilepsy (2012)
Epilepsia Roopra A, Dingledine R, Hsieh J
10.1111/epi.12030.
View PublicationFunctional and mechanistic exploration of an adult neurogenesis-promoting small molecule (2012)
FASEB J Petrik D, Jiang Y, Birnbaum SG, Powell CM, Kim MS, Hsieh J, Eisch AJ.
10.1096/fj.11-201426.
View PublicationOrchestrating transcriptional control of adult neurogenesis (2012)
Genes Dev Hsieh J
10.1101/gad.187336.112.
View PublicationProfiling of REST-Dependent microRNAs Reveals Dynamic Modes of Expression (2012)
Front Neurosci Gao Z, Ding P, Hsieh J
10.3389/fnins.2012.00067
View PublicationSmall-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression (2011)
Differentiation Ling Zhang, Peng Li, Tiffany Hsu, Jay Schneider, Robert Bachoo, and Jenny Hsieh
10.1016/j.diff.2011.02.005.
View PublicationThe master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells. (2011)
Neuroscience Zhengliang Gao, Kerstin Ure, Mostafa Nashaat, Laura Yuan, Robert Hammer, and Jenny Hsieh
10.1523/JNEUROSCI.
View PublicationDiscovery of a proneurogenic, neuroprotective chemical (2010)
neuroprotective chemical AA Pieper, S Xie, E Capota, SJ Estill, J Zhong, JM Long, GL Becker, P Huntington, SE Goldman, CH Shen, M Capota, JK Britt, T Kotti, K Ure, DJ Brat, NS Williams, KS MacMillan, J Naidoo, L Melito, J Hsieh, J De Brabander, JM Ready, and SL McKnight
10.1016/j.cell.2010.06.018.
View PublicationEpigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: unraveling the genome to understand the mind (2010)
Neurobiology of Disease Jenny Hsieh, and Amelia J Eisch
10.1016/j.nbd.2010.01.008
View PublicationMicroRNA regulation of neural stem cells and neurogenesis (2010)
Neuroscience Yanhong Shi, Xinyu Zhao, Jenny Hsieh, Hynek Wichterle, Soren Impey, Sourav Banerjee, Pierre Neveu, and Kenneth S. Kosik
10.1523/JNEUROSCI.4280-10.2010.
View PublicationNotch1 is required for maintenance of the reservoir of adult hippocampal stem cells. (2010)
Neuroscience JL Ables, NA Decarolis, MA Johnson, PD Rivera, Z Gao, DC Cooper, F Radtke, J Hsieh, and AJ Eisch
10.1523/JNEUROSCI.4721-09.2010.
View PublicationHDAC1 and HDAC2 Regulate Oligodendrocyte Differentiation By Disrupting β-Catenin-TCF Interaction (2009)
Nature Neuroscience Feng Ye, Ying Chen, Thao Nguyen Hoang, Rusty Montgomery, Hong Bu, Xiang-hui Zhao, Tom Hu, Johan van Es, Hans Clevers, Makoto Taketo, Jenny Hsieh, Rhonda Bassel-Duby, Eric N. Olson, and Q. Richard Lu
10.1038/nn.2333.
View PublicationHistone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development (2009)
Proc Natl Acad Sci USA Rusty Montgomery, Jenny Hsieh, Ana Barbosa, James Richardson, and Eric N. Olson
10.1073/pnas.0902750106.
View PublicationNeurod1 is essential for the survival and maturation of adult-born neurons (2009)
Nature Neuroscience Zhengliang Gao, Kerstin Ure, Jessica Ables, Diane Lagace, Sandra Goebbels, Klause-Armin Nave, Amelia Eisch, and Jenny Hsieh
10.1038/nn.2385
View PublicationThe oligodendrocyte-specific G-protein coupled receptor GPR17 is a cell-intrinsic timer of myelination (2009)
Nature Neuroscience Ying Chen, Heng Wu, Hisami Koito, Jianrong Li, Jenny Hoang, Shuzong Wang, Sabine S. Escobar, Alex Gow, Heather A. Arnett, Bruce D. Trapp, Nitin J. Karandikar, Jenny Hsieh and Q. Richard Lu
10.1038/nn.2410
View PublicationWnt-mediated activation of NeuroD1 and retroelements during adult neurogenesis (2009)
Nature Neuroscience Tomoko Kuwabara, Jenny Hsieh, Alysson Muotri, Gene Yeo, Masaki Warashina, D. Chichung Lie, Lynne Moore, Kinichi Nakashima, Makoto Asashima, Fred H. Gage
10.1038/nn.2360.
View PublicationCardiogenic small molecules that enhance stem cell function in myocardial repair (2008)
Proc Natl Acad Sci USA Hesham Sadek, Britta Hannack, Elizabeth Choe, Jessica Wang, Shuaib Latif, Mary G. Garry, Daniel J. Garry, Jamie Longgood, Douglas E. Frantz, Eric N. Olson, Jenny Hsieh, and Jay W. Schneider
10.1073/pnas.0711507105.
View PublicationEpigenetic regulation of neural cell differentiation plasticity in the adult mammalian brain (2008)
Proc Natl Acad Sci USA Jun Kohyama, Takuro Kojima, Eriko Takatsuka, Toru Yamashita, Jun Namiki, Jenny Hsieh, Fred H. Gage, Masakazu Namihira, Hideyuki Okano, Kazunobu Sawamoto, and Kinichi Nakashima
10.1073/pnas.0808417105.
View PublicationSmall-molecule activation of neuronal cell fate (2008)
Nature Chemical Biology Jay W. Schneider, Zhengliang Gao, Shijie Li, Midhat Farooqi, Tie-Shan Tang, Ilya Bezprozvanny, Douglas E. Frantz, and Jenny Hsieh
10.1038/nchembio.95
View PublicationEpigenetic modulation of seizure-induced neurogenesis and cognitive decline (2007)
Neuroscience Sebastian Jessberger, Kinichi Nakashima, Gregory Clemenson, Eunice Mejia, Emily Mathews, Kerstin Ure, Shiori Ogawa, Christopher M. Sinton, Fred H. Gage, and Jenny Hsieh
10.1523/JNEUROSCI.0110-07.2007
View PublicationChromatin remodeling in neural development and plasticity (2005)
Current Opinion in Cell Biology Jenny Hsieh, and Fred H. Gage
10.1016/j.ceb.2005.09.002
View PublicationA small modulatory dsRNA specifies the fate of adult neural stem cells (2004)
Cell Tomoko Kuwabara, Jenny Hsieh, Kinichi Nakashima, Kazunari Taira, and Fred H. Gage
10.1016/s0092-8674(04)00248-x
View PublicationEpigenetic control of neural stem cell fate (2004)
Current Opinion in Genetics & Development Jenny Hsieh, and Fred H. Gage
10.1016/j.gde.2004.07.006
View PublicationHDAC inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells (2004)
Proc Natl Acad Sci USA Jenny Hsieh, Kinichi Nakashima, Tomoko Kuwabara, Eunice Mejia, and Fred H. Gage.
10.1073/pnas.0407643101
View PublicationIGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes (2004)
Cell Biology Jenny Hsieh, James B. Aimone, Brian K. Kaspar, Tomoko Kuwabara, Kinichi Nakashima, and Fred H. Gage
10.1083/jcb.200308101
View PublicationIncreased neurogenesis in dentate gyrus of long-lived Ames dwarf mice (2004)
Endocrinology Liou Y. Sun, M. Steven Evans, Jenny Hsieh, Jacob Panici, and Andrzej Bartke
10.1210/en.2004-1115.
View PublicationRecognition and silencing of repeated DNA. (2000)
Annual Review of Genetics Jenny Hsieh, and Andrew Fire
10.1146/annurev.genet.34.1.187
View PublicationThe RING finger/B-Box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans (1999)
Genes and Development Jenny Hsieh, Jing Liu, Steve Kostas, Chieh Chang, Paul Sternberg, and Andrew Fire
10.1101/gad.13.22.2958
View Publication